NIDCD Research Grants for Translating Basic Research into Clinical Practice (R01 Clinical Trials Optional)
NIH -National Institute on Deafness and Other Communication Disorders (NIDCD)
Description: This opportunity provides an avenue for basic scientists, clinicians, and clinical scientists to jointly initiate and conduct research projects that translate basic research findings into clinical practice that will impact the diagnosis, treatment, and prevention of disorders within NIDCD’s scientific mission. Connection to the clinical condition must be clearly established and the outcomes of the proposed work must have practical clinical impact in the near term. Early engagement with end users (e.g., practicing clinicians, patients) in real-world environments in which these approaches will be employed is expected.
- Possible goals in an application may include, but are not limited to:
- Biochemical, electrophysiological, and behavioral assays to enhance diagnostic capabilities.
- Pharmacology, toxicity, and pharmacokinetic analysis for candidate therapeutics that have demonstrated potential for the treatment of communication disorders in humans.
- Preclinical research for dosage studies and toxicity when a subsequent Phase I/II clinical trial is anticipated in the near term and if the non-huan studies have received NIDCD pre-approval.
- Translation of new tools and techniques for better diagnostics or therapeutics including, but not limited to, neuroprosthetic devices, drug delivery devices, neuro-electrical stimulators and recording devices.
- Translation of laboratory-based screening tests into improved ways to identify individuals at risk for a communication disorder to allow for early intervention.
- Translation of published basic research findings into new clinical applications that support precision approaches to intervention and improve prognostic efficacy.
- Implementation of discoveries from biological, psychological, social sciences and other related areas into innovative prevention, diagnosis, and treatment paradigms, including early engagement of end users (e.g., clinicians, patients).
- Modification of laboratory measures of function or laboratory treatment protocols for use in clinical settings.
Open Date (Earliest Submission Date): January 13, 2025
Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): Feb. 13, 2025; Oct. 13, 2025; June 12, 2026; Feb. 12, 2027; Oct. 12, 2027
Maximum Project Period: 5 years
Maximum Amount: maximum funding per grant less than $500,000 direct costs per year
Additional Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DC-25-002.html