Back to Top Skip to main content Skip to sub-navigation

Smallpox (ACAM2000)

DoD Smallpox Vaccination Program Resource Center

Smallpox Disease and Smallpox Vaccine information paper (includes updated guidance on avoiding contamination while drawing vaccine from the vial)

Questions and Answers about Smallpox and Smallpox Vaccine

SmallpoxSmallpox disease had a mortality rate of approximately 30 percent, and because of a successful vaccination program it was declared globally eradicated in 1980. Naturally occurring smallpox was highly contagious, and was transmitted from an infected person to a susceptible (unvaccinated) person by close contact with respiratory secretions and/or infected skin. When smallpox disease was circulating, the only known reservoir for the virus was humans.

Once infected, a person usually has no symptoms and is not contagious during the incubation period, which ranges from 7-17 days.  Symptoms then begin with high fever, headache, body aches and fatigue. This may last 2-4 days, and then the rash develops. The rash first appears on the oral mucosa, face, and forearms, then spreads to the trunk and legs. A person is most infectious during the first week of the rash and is no longer infectious after all scabs have separated, usually 3-4 weeks after onset.

There is currently one smallpox vaccine licensed in the United States, ACAM2000, and is given in a pre-event setting only to select, designated groups including certain members of the U.S. military. The smallpox vaccine is administered in a single dose by the percutaneous route (scarification) using 15 jabs with a stainless steel bifurcated needle that has been dipped into the reconstituted vaccine. A few days following successful administration of the vaccine, a lesion forms at the vaccination site. This lesion contains vaccinia virus capable of infecting other parts of your body or infecting others who come in contact with the vaccination site directly or anything that contains drainage from the lesion.  For this reason, all smallpox vaccinees are taught, and must practice, proper vaccination site and dressing care. 

Source: Centers for Disease Control and Prevention

You also may be interested in...

Approval of Army Smallpox Implementation Plan


MEDCOM Smallpox Guidance


Smallpox Vaccine Exemption Codes


Military Medical Exemption Codes for Smallpox (Vaccinia) Vaccination in a Non-Emergency Situation

Recommended Content:

Smallpox (ACAM2000)

Education and Training for Medical Personnel to Prepare for Smallpox Vaccinations


Policy on Administrative Issues Related to Smallpox Vaccination


Smallpox Response Plan

<< < 1 2 3 4 5 > >> 
Showing results 61 - 66 Page 5 of 5
Last Updated: January 21, 2020

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing. Download a PDF Reader or learn more about PDFs.