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Smallpox (Jynneos)

Jynneos Smallpox/Mpox Vaccine Resource Center

On September 24, 2019, the U.S. Food and Drug Administration approved the first live, non-replicating vaccine for prevention of smallpox and mpox disease in adults 18 years of age and older determined to be at high risk for smallpox or mpox infection.

While there is currently no vaccine available from the manufacturer for use, the Department of Defense and other government partners are engaged in robust discussions regarding future deployment of this vaccine within the military.

Further information will be provided once available.

Resource Center

You will find below all of the resources you will need about the Jynneos smallpox/mpox vaccine. More will be added as they are published or released.

Vaccine Information Statements Date
Smallpox/Mpox Vaccine (JYNNEOS™): What You Need to Know
Nov. 14, 2022
Information Paper Date
When Pregnancy Is Discovered After Smallpox Vaccination - Smallpox Vaccine in Pregnancy Registry
Oct. 26, 2022
Forms Date
VAERS Smallpox Pregnancy Supplemental Form
Nov. 14, 2022
Storage and Handling Date
Clarification on JYNNEOS storage and handling requirements (Manufacturer letter clarifying that JYNNEOS may be refrigerated for up to 8 weeks after initial thaw. This differs from the package insert.)
June 14, 2022
CDC: JYNNEOS Smallpox and Mpox Vaccine Preparation and Administration Summary Sept. 27, 2023
Manufacturer Package Inserts Date
JYNNEOS
Sept. 29, 2023
Advisory Committee on Immunization Practices Recommendations Date
Jynneos Smallpox/Mpox Vaccine
June 3, 2022
Last Updated: December 04, 2023
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