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Research Regulatory Oversight Office

The Research Regulatory Oversight Office (R2O2) is responsible for oversight of DoD-conducted and -supported research activities involving humans and animals to ensure compliance with all legal and ethical requirements. Our oversight responsibility includes:

  • Research involving human subjects
  • Research and testing with animals
  • Implementation of the research integrity and misconduct rules

The scope of our oversight includes all institutions under the purview of the Under Secretary of Defense for Personnel and Readiness (P&R).

Our Programs

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Defense Medical Research Network

Fact Sheet
5/21/2015

The Defense Medical Research Network is a DoD-wide web-based solution for research management, compliance, and oversight needs. The network is a place to store and access data, search and share submissions, network with members of the DoD medical research community, gain guidance and support, and manage related aspects of the research process – ...

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Part II: DoD and OUSD (P&R) Specific and Unique Requirements

Policy

Outlines specific and unique requirements for Research Oversight.

Consent Checklist

Form/Template
5/20/2015

DoD Directive 3216.02 defines research involving a human being as an experimental subject as an activity, for research purposes, where there is an intervention or interaction with a human being for the primary purpose of obtaining data regarding the effect of the intervention or interaction. Examples of interventions or interactions include, but are ...

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Research Regulatory Oversight Office

PHS Policy on Humane Care and Use of Laboratory Animals

Policy

The 2015 reprint of the PHS Policy reflects the following changes from the 2002 reprint: (1) On January 1, 2012, OLAW adopted the Guide for the Care and Use of Laboratory Animals: Eighth Edition (Guide), an update of the 1996 Seventh Edition, released by the National Academy of Sciences Institute for Laboratory Animal Research (ILAR) in 2011.

AVMA Guidelines for Euthanasia of Animals

Policy

The AVMA Guidelines for the Euthanasia of Animals are intended for use by members of the veterinary profession who carry out or oversee the euthanasia of animals. The overriding commitment of these Guidelines is to provide veterinarians guidance in relieving pain and suffering of animals that are to be euthanized.

Guide for DoD Researchers on Using MHS Data

Publication
10/10/2012

This document is a guide for Department of Defense (DoD) researchers who plan to request Military Health System (MHS) data for research purposes, in particular, for database research.

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Research Regulatory Oversight Office

Minimum Education Requirements for DoD Personnel Involved in Human Research Protection

Report
8/16/2012

This document outlines the minimum education requirements for DoD personnel involved in human research protection.

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DoD Instruction 3216.02: Protection of Human Subjects and Adherence to Ethical Standards in DoD-Supported Research

Policy

This Instruction reissues DoD Directive (DoDD) 3216.02 as a DoD Instruction in accordance with the authority in DoDD 5134.01 to establish policy and assign responsibilities for the protection of human subjects in DoD-supported programs to implement part 219 of title 32, Code of Federal Regulations (CFR) (also known and hereinafter referred to as β€œthe Common Rule.”

DFAR Human Subject Protection Clause

Presentation
9/15/2011

An introduction and overview for contracting offices supporting the OUSD/P&R

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Research Regulatory Oversight Office

Individual Investigator Agreement

Form/Template
3/29/2011

This form is a tool that can be used when a collaborating investigator is not part of an institution with a federal assurance.

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Research Regulatory Oversight Office

Guide for the Care and Use of Laboratory Animals

Policy

The purpose of the Guide for the Care and Use of Laboratory Animals (the Guide), as expressed in the charge to the Committee for the Update of the Guide, is to assist institutions in caring for and using animals in ways judged to be scientifically, technically, and humanely appropriate.

Animal Welfare

Policy

48 CFR 252.235-7002: Animal Welfare

DoD Instruction 3216.01: Use of Animals in DoD Programs

Policy

This Instruction reissues DoD Directive (DoDD) 3216.1 (Reference (a)) as a DoD Instruction (DoDI) in accordance with the authority in DoDD 5134.01 (Reference (b)) to establish policy and assign responsibilities for the use of animals in DoD programs. The Reference (a) designation of the Secretary of the Army as the DoD Executive Agent to develop and issue Service regulations to implement Reference (a) has been cancelled pursuant to Deputy Secretary of Defense Memorandum (Reference (c)).

Research Regulatory Oversight Office

Presentation
9/1/2010

This presentation provides an overview of the Research Regulatory Oversight Office

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Research Regulatory Oversight Office

Institutional Agreement for IRB Review

Form/Template
8/30/2010

This form should be used when an institution will be engaged in human subject research and will use an Institutional Review Board (IRB) that is not organizationally or legally part of the institution.

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Research Regulatory Oversight Office
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