Back to Top Skip to main content
Alert Arrow ALERT!!

There are emergency procedures in place for parts of world due to weather.

Get the latest information on emergency prescription refills and PCM referral waivers. 

First-ever blood test for detecting brain injury cleared by FDA

Research found two proteins rapidly appear in the blood following a blow or jolt to the head when a serious traumatic brain injury occurs.  Now there is a blood test that can identify whether the proteins are in the blood or not. With the blood test as a diagnostic tool, medical professionals can rule out more serious brain injuries while evaluating someone with a suspected concussion. (U.S. Air Force photo by Staff Sgt. Teresa J. Cleveland) Research found two proteins rapidly appear in the blood following a blow or jolt to the head when a serious traumatic brain injury occurs. Now there is a blood test that can identify whether the proteins are in the blood or not. With the blood test as a diagnostic tool, medical professionals can rule out more serious brain injuries while evaluating someone with a suspected concussion. (U.S. Air Force photo by Staff Sgt. Teresa J. Cleveland)

Recommended Content:

Traumatic Brain Injury

FALLS CHURCH, Va. — You’re throwing a football around in the yard with your neighbors. While stretching out as far as you can to catch the pass, you slam your head hard against a pole going for the ball. Seeing stars and feeling confused, you take a seat. Wouldn’t it be nice if a test could say whether you have a brain injury?

Brain injury can happen from a fall, while in combat, or during training exercises. Thanks in part to research funded by the Dept. of Defense and the U.S. Army, Banyan Biomarkers has created the first-ever brain trauma blood test. On Feb. 14, the Food and Drug Administration (FDA) cleared marketing of the Banyan Biomarkers’ Brain Trauma Indicator, or BTI ™.

The BTI can identify two brain-specific protein markers, called UCH-L1 (Ubiquitin Carboxy-terminal Hydrolase-L1) and GFAP (Glial Fibrilliary Acidic Protein). These proteins rapidly appear in the blood and are elevated 12 hours following an incident where a head injury occurs and can signify if there is bleeding in the brain. The two protein markers won’t be elevated if your brain is uninjured or if you have a mild traumatic brain injury (TBI), otherwise known as a concussion.

"When these proteins are elevated, there may be blood in the brain,” said Kathy Helmick, acting director of the Defense and Veterans Brain Injury Center (DVBIC). “A hematoma, or blood in the brain, may indicate a more serious brain injury has occurred, which could require rapid evacuation for neurosurgery to remove a clot in the brain.”  

The first thing a doctor tries to rule out with suspected brain injury is the potential for serious complications, like losing consciousness, going into a coma, or death. According to the research results and FDA clearance, the blood test can help medical professionals determine the need for computed tomography (CT) scans in patients suspected of having a concussion.  It also can help prevent unnecessary radiation exposure for patients.

Prior to discovering these biological protein markers, medical professionals had to rely on symptom reporting and other more subjective means to evaluate patients with few signals of more serious head injury.

“This technology helps us identify red flags after you suspect a head injury so that you can get the person to definitive care,” Helmick explained. “Most times, the blood test will be negative and the medical provider will continue with a concussion evaluation.”

Lt. Col. Kara Schmid said U.S. Army Medical Research and Materiel Command will “begin limited user testing with the device in the first quarter of fiscal year 2019.” Schmid is a project manager for the Neurotrauma and Psychological Health Project Management Office at the U.S. Army Medical Materiel Development Activity. “Improvements could make the device more supportable by the military health system.”

The Department of Defense has been seeking a method for diagnosing and evaluating TBI in service members for over a decade. According to DVBIC, over 375,000 service members have been diagnosed with TBI since 2000. Approximately 82 percent of those TBI cases are classified as a concussion.

According to Kelley Brix, MD – who is a branch chief for interagency research and development at the Defense Health Agency – the need for diagnosing milder forms of brain injury sparked research questions that were funded as part of a greater TBI research portfolio.

“The research question became centered on if the brain releases anything detectable into the blood stream when there is damage,” said Brix. “The answer is yes. This is a big project with a successful outcome. But, it's only part of our large portfolio looking at improved ways to diagnose and treat TBI."

Helmick says knowing whether blood, swelling, or bruising on the brain has taken place helps with understanding the severity of the TBI.

“These two proteins give us a window of insight into what is going on in the brain,” said Helmick. “We have lacked objective devices and data in TBI, especially with concussion. The reason biological markers are so important is because they are accurate, sensitive, and objective."

Making the machine required to run the blood test smaller and more portable is a work in progress, as currently it’s intended for use in a laboratory. Logistical constraints of the BTI device make deployment to the force a challenge.

“There is active work going on to reduce the 3-4 hour time frame for getting test results, which could make it even more usable for austere environments,” Helmick said. “This blood test is an example of a significant public-private success and a huge advancement in the field of TBI."


You also may be interested in...

Diagnoses of Traumatic Brain Injury Not Clearly Associated with Deployment, Active Component, U.S. Armed Forces, 2001 – 2016

Infographic
4/4/2017
Traumatic Brain Injury (TBI) is structural alteration of the brain or physiological disruption of brain function caused by an external force.  TBI, particularly mild TBI or concussion, is the most common traumatic injury in the U.S. military. This analysis provides the estimated rates of incident TBIs among service members before their first-ever deployment as well as separately among service members during deployments/ after deployments. It also mentions factors that may explain why the TBI incidence rates among the previously deployed were higher than those of the never-deployed group. Moreover, it describes the demographic and military traits of service members diagnosed as TBI cases (before/after deployment). Categorization of person time during surveillance period included four categories: Group 1 (Never deployed/TBI before first-ever deployment), Group 2 (Currently deployed or within 30 days of return), Group 3 (previously deployed but not currently deployed nor within 30 days of return) and Censored after Diagnosis of TBI. From 2001-2016, 276,858 active component service members received first-time diagnoses of TBI. The crude overall incidence rate of TBI among deployed service members was 1.5 times that of service members assigned to Group 1 and 1.2 times that of service members in Group 3 during the surveillance period.  Total TBI cases by group were Group 1 42.8%, Group 2 13.2% and Group 3 44.0%. Incidence rates by group (per 100,000 person-years) were Group 1 1,141.3, Group 2 1,690.5, and Group 3 1,451.2. Learn more at www.Health.mil/MSMR and see fact sheets at www.Health.mil/AFHSB

Traumatic Brain Injury (TBI) is structural alteration of the brain or physiological disruption of brain function caused by an external force. TBI, particularly mild TBI or concussion, is the most common traumatic injury in the U.S. military. This analysis provides the estimated rates of incident TBIs among service members before their first-ever ...

Recommended Content:

Traumatic Brain Injury | Armed Forces Health Surveillance Branch
<< < 1 > >> 
Showing results 1 - 1 Page 1 of 1

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing: Download a PDF Reader or learn more about PDFs.