Back to Top Skip to main content

World AIDS Day puts spotlight on landmark DoD study

Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration.  (U.S. Army photo) Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center, discusses HIV vaccine progress at the Walter Reed Army Institute of Research, Nov. 26, during a World AIDS Day commemoration. (U.S. Army photo)

Recommended Content:

Immunization Healthcare | Research and Innovation | Global Health Engagement

The Walter Reed Army Institute of Research (WRAIR) hosted a World AIDS Day event Tuesday, Nov. 26, highlighting advances in DoD-led HIV research and celebrating the 10th anniversary of the Army-led RV144 HIV vaccine study.

WRAIR’s Military HIV Research Program or MHRP headed the RV144 study, the first-ever – and only to-date – clinical trial to demonstrate that an HIV vaccine regimen was safe and modestly effective in preventing HIV infection. The study sought to determine what methods could be used to lower risk of contracting the disease.

The RV144 trial represented a massive undertaking for the Army and serves as a model of international and interagency collaboration. It involved more than 16,000 adult volunteers and a large network of partners who still work with WRAIR today, including the Thai Ministry of Public Health; the National Institute of Allergy and Infectious Diseases – part of the National Institutes of Health; and Sanofi Pasteur.

In 2009, the Army announced that the study’s investigational prime-boost vaccine regimen lowered the rate of HIV infection by 31.2 percent. These results, although modest, gave the global community hope that a vaccine to prevent HIV infection is possible at a time when such an achievement seemed elusive.

“RV144 was the light at the time in the field, without which we may have given up,” said Dr. John Mascola, director of the National Institutes of Health Vaccine Research Center and the featured speaker at WRAIR’s World AIDS Day event. “In the last 10 years of HIV vaccine progress, RV144 is the anchor.”

The landmark trial continues to provide scientific direction to help guide vaccine development and testing. RV144 and its follow-on trials allowed researchers to discover of risk factors, provide targets for optimizing vaccine boosting, and form a foundation for three HIV vaccine candidates currently undergoing efficacy testing. A video featuring many prominent HIV researchers who were involved with RV144 was shown at the World AIDS Day event.

Also at the event, Lt. Gen (Ret.) Eric B. Schoomaker, 42nd surgeon general of the United States Army and former commanding general of the United States Army Medical Command, highlighted the military’s earliest contributions to HIV research, which include the development of a disease staging system and promoting the finding that HIV can be transmitted heterosexually. The military’s HIV research efforts were consolidated in 1986 with the establishment of MHRP.

MHRP’s initial mission was to advance an HIV vaccine to protect service members and the global community from HIV, but has since expanded beyond vaccine development to include cure research and prevention and treatment services in Africa under the President’s Emergency Plan for AIDS Relief or PEPFAR. Via PEPFAR initiatives, WRAIR provides life-saving antiretroviral therapy to more than 350,000 people living with HIV in sub-Saharan Africa, which contributes to global health security.

WRAIR supports PEPFAR activities within military and civilian communities in four countries where it conducts research (Nigeria, Tanzania, Uganda, and Kenya), which strengthens community trust and provides an ethical framework for clinical studies. The Department of Defense HIV/AIDS Prevention Program, led by the U.S. Navy, is responsible for assisting foreign military partners with the development and implementation of military-specific HIV/AIDS prevention and treatment programs in more than 55 countries around the globe, also supported by PEPFAR.

“Those countries that partner with us on PEPFAR have a 40-percent decrease in violence and a 40-increase in political stability,” said WRAIR Commander Army Col. Deydre Teyhen. “So we say that soldier health is world health. But in fighting HIV/AIDS, WRAIR researchers are also working to advance world peace.”

More information can be found on the RV144 HIV Trial web page.

You also may be interested in...

Immunization Tool Kit 9th Edition

Publication
10/25/2018

A practical reference that facilitates and enhances the global delivery of quality immunization healthcare to Department of Defense (DoD) beneficiaries and employees. The Defense Health Agency Immunization Healthcare Branch (DHA-IHB) publishes the Immunization Tool Kit based on national recommendations, evidenced-based, peer-reviewed published medical literature, and clinical practice guidelines.

Recommended Content:

Immunization Healthcare

WRAIR begins Phase 1 clinical trial of Marburg vaccine

Article
10/19/2018
The WRAIR study evaluates the VRC-MARADC087-00-VP vaccine, developed by the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases, National Institutes of Health. (U.S. Army file photo)

WRAIR recently administered the first vaccine in a Phase 1 clinical trial to evaluate the safety and immunogenicity of a Marburg vaccine

Recommended Content:

Immunization Healthcare | Immunizations

Navy entomologists team up to build disease detection capacity in Honduras

Article
10/18/2018
Navy LCDR Kimberly Edgel (right) and Carmen Lucas examine a positive malaria blood smear at U.S. Naval Medical Research Unit, or NAMRU, 6 in Callao, Peru. (U.S. Navy photo)

Leishmaniasis, malaria, dengue and Chagas disease are known to be present in Honduras

Recommended Content:

Global Health Engagement

Bringing Comfort 2018

Video
10/17/2018
The USNS Comfort is a state-of-the-art hospital ship, and it’s scheduled to deploy to Central and South America for Continuing Promise 2018.

The USNS Comfort is a state-of-the-art hospital ship, and it’s scheduled to deploy to Central and South America for Continuing Promise 2018.

Recommended Content:

Global Health Engagement

Vaccination Coverage Among Children Aged 19–35 Months — United States, 2017

Report
10/12/2018

The Advisory Committee on Immunization Practices recommends routine vaccination by age 24 months against 14 potentially serious illnesses. In 2017, coverage with most recommended vaccines among children aged 19–35 months remained stable and high but was lower in more rural areas and among uninsured or Medicaid-insured children.

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Vaccine Schedules

Vaccination Coverage for Selected Vaccines and Exemption Rates Among Children in Kindergarten — United States, 2017–18 School Year

Report
10/12/2018

Immunization programs conduct annual kindergarten vaccination assessments to monitor school-entry vaccination coverage for all state-required vaccines. Median vaccination coverage was 94.3% for 2 doses of measles, mumps, and rubella vaccine; 95.1% for the state-required number of doses of diphtheria and tetanus toxoids and acellular pertussis vaccine; and 93.8% for 2 doses of varicella vaccine.

Recommended Content:

Immunization Healthcare | Vaccine-Preventable Diseases | Vaccine Schedules

Sailors, Afghan medical professionals team up to improve medical care

Article
10/10/2018
Navy Lt. Cdr. Travis J. Fitzpatrick, senior nurse for Kandahar Airfield NATO Role III Multinational Medical Unit, demonstrates a technique on how to clear the airway of a patient to Afghan medical staff members during a medical advisory visit at Kandahar Regional Military Hospital, Camp Hero in Kandahar, Afghanistan. Staff members from the Role III conduct routine visits to KRMH to train and advise Afghan medical staff. (U.S. Army photo by Staff Sgt. Neysa Canfield)

The Kandahar Regional Military Hospital is run by Afghan military and civilian medical professionals

Recommended Content:

Global Health Engagement | Building Partner Capacity and Interoperability | Partners | Global Health Security Agenda

USNS Comfort to deploy to Central and South America

Article
10/9/2018
The U.S. Navy hospital ship USNS Comfort is scheduled to depart Naval Station Norfolk, Virginia, en route to South America and Central America where it will conduct an 11-week medical assistance mission working closely with host-nation health and government partners in Ecuador, Peru, Colombia, and Honduras. This mission marks the sixth time the hospital ship will provide medical assistance in the region and reflects the United States’ enduring promise of friendship, partnership, and solidarity with the Americas. (U.S. Navy file photo)

The ship’s crew will include more than 200 U.S. and partner nation military doctors, nurses and technicians

Recommended Content:

Global Health Engagement | Partners | Global Health Security Agenda

Say ‘Shoo’ to the flu with TRICARE

Article
9/26/2018
Amanda LaFountain, a licensed practical nurse, administers the flu shot to a Soldier. (U.S. Army photo by Staff Sgt. Marshall Metzger)

Flu viruses are serious, contagious viruses that can lead to hospitalization or even death

Recommended Content:

Health Readiness | Immunization Healthcare | Public Health

Navy Medicine global health team conducts trauma exchange in Vietnam

Article
8/28/2018
The 13 Navy Medicine members stand together on the first day of the Integrated Trauma and Medical Readiness Exchange engagement in Vietnam. (U.S. Navy photo by Capt. Joel Roos)

Sharing trauma management skills was the focus of this exchange

Recommended Content:

Global Health Engagement

Awards honor distinguished service, individual and team research

Article
8/21/2018
Pictured are the recipients of the 2018 MHSRS Awards, including the 2018 MHSRS Distinguished Service Award, the individual achievement in research awards, and the research team awards. Right to left are Air Force Maj. Joseph K. Maddry, Army Col. Michael P. Kozar, Kenneth M. Hargreaves, DDS, Ph.D., Navy Lt. Cmdr. Micah Gaspary, Australian Defence Force Col. Michael Reade, Army Col. Andrew P. Cap, Dr. Thomas Joiner and Dr. Peter Gutierrez. (MHS photo)

Three people, four teams recognized at symposium

Recommended Content:

MHSRS 2019 | Research and Innovation

Premier scientific symposium showcases medical research and development

Article
8/20/2018
Dr. Terry Adirim, deputy assistant secretary of defense for Health Services Policy and Oversight, speaks at a plenary session at the 2018 Military Health System Research Symposium, Aug. 20, at the Gaylord Palms Resort and Convention Center in Kissimmee, Florida. The theme of this year’s meeting is “Medical Innovation for Warfighter Readiness: The Future Starts Now.” (MHSRS photo)

Recommended Content:

MHSRS 2019 | Research and Innovation

Researchers will present findings at Military Health System Research Symposium

Article
8/15/2018
The theme of this year’s meeting is “Medical Innovation for Warfighter Readiness.”

As the DoD’s premier scientific meeting, MHSRS helps to facilitate the exchange of information between almost 3,000 attendees

Recommended Content:

MHSRS 2019 | Research and Innovation

Medical research and development take center stage at symposium

Article
8/15/2018
The theme of this year’s meeting is “Medical Innovation for Warfighter Readiness.”

Premier scientific meeting to draw 3,000 attendees

Recommended Content:

MHSRS 2019 | Research and Innovation

U.S. doctors save Italian patient hours from death

Article
8/8/2018
U.S. Air Force Capt. Melanie Gates, left, Capt. Nick McKenzie, and Capt. Richard Thorsted, all who are Special Operations Command Forward Northwest Africa ground surgical team members, gather for a photo at Nigerien Air Base 101, Niamey. The three doctors recently finished medical school and are serving their first deployment. They are deployed from Travis Air Force Base, California. (U.S. Air Force courtesy photo)

The patient had a fever, a very high heart rate and low oxygen levels

Recommended Content:

Health Readiness | Global Health Engagement | Partners
<< < 1 2 3 4 5  ... > >> 
Showing results 61 - 75 Page 5 of 17

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing. Download a PDF Reader or learn more about PDFs.