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Update: Malaria, U.S. Armed Forces, 2019

An Anopheles gambiae mosquito in the process of obtaining a blood meal. Credit: CDC/James D. Gathany An Anopheles gambiae mosquito in the process of obtaining a blood meal. Credit: CDC/James D. Gathany

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Medical Surveillance Monthly Report

ABSTRACT

Malaria infection remains an important health threat to U.S. service members who are located in endemic areas because of long-term duty assignments, participation in shorter-term contingency operations, or personal travel. In 2019, a total of 35 service members were diagnosed with or reported to have malaria. This represents a 40.7% decrease from the 59 cases identified in 2018. The relatively low numbers of cases during 2012–2019 mainly reflect decreases in cases acquired in Afghanistan, a reduction due largely to the progressive withdrawal of U.S. forces from that country. Although the number of cases of malaria caused by Plasmodium falciparum decreased in 2019, the percentage of such cases (54.3%) was the highest during any given year of the 2010–2019 surveillance period. Eleven cases of malaria were attributed to an unspecified/other source (31.4%). The number of malaria cases caused by P. vivax (n=5) was one of the lowest observed during the 10-year surveillance period, and the percentage (14.3%) of such cases remained one of the lowest. Malaria was diagnosed at or reported from 17 different medical facilities in the U.S., Germany, Afghanistan, and Korea. Providers of medical care to military members should be knowledgeable of and vigilant for clinical manifestations of malaria outside of endemic areas.

WHAT ARE THE NEW FINDINGS?    

The 2019 total of 35 malaria cases among active and reserve component service members was tied with the 2017 total for the lowest annual counts of cases during the past 10 years. The 2019 proportion of cases (54.3%) due to P. falciparum was the highest of the 10-year period.

WHAT IS THE IMPACT ON READINESS AND FORCE HEALTH PROTECTION?

The decrease in total counts of malaria cases during the last decade and the increased proportion of cases due to P. falciparum both reflect the reduced numbers of service members exposed to malaria (especially P. vivax) in Afghanistan. The persistent threat from P. falciparum associated with duty in Africa underscores the importance of preventive measures effective against this most dangerous strain of malaria.

BACKGROUND

Globally, the incidence rate of malaria is estimated to have decreased by 19.7% between 2010 and 2018, from 71 to 57 cases per 1,000 population at risk between 2010 and 2018.1 However, for the third consecutive year, the World Health Organization reported a relative plateauing in the numbers of cases and rates of malaria: in 2018, there were an estimated 228 million cases of malaria compared to 231 million in 2017 and 227 million in 2016; the incidence rate had decreased to 57 per 1,000 population at risk in 2014 but remained steady through 2018.1 During the 6 years prior, the number of people contracting malaria globally had been steadily decreasing, from 251 million in 2010 to 219 million in 2015.1

Countries in Africa accounted for around 93% of worldwide malaria cases and 94% of all malaria-related deaths in 2018.The majority of these cases and deaths were due to mosquito-transmitted Plasmodium falciparum and occurred in sub-Saharan Africa among children under 5 years of age, but P. vivaxP. ovale, and P. malariae can also cause severe disease. 1,2Globally, 3.3% of estimated malaria cases are due to P. vivax; however, 85% of vivaxmalaria cases occurred in 6 countries including India, Afghanistan, Pakistan, Ethiopia, Papua New Guinea, and Indonesia.1

The MSMR has published annual updates on the incidence of malaria among U.S. service members since 2001 (the first 6 updates were limited to Army members).3 The MSMR’s focus on malaria reflects both historical lessons learned about this mosquito-borne disease and the continuing threat that it poses to military operations and service members’ health. Malaria infected many thousands of service members during World War II (approximately 695,000 cases), the Korean War (approximately 390,000 cases), and the conflict in Vietnam (approximately 50,000 cases).4,5 More recent military engagements in Africa, Asia, Southwest Asia, the Caribbean, and the Middle East have necessitated heightened vigilance, preventive measures, and treatment of cases.6–15

In the planning for overseas military operations, the geography-based presence or absence of the malaria threat is usually known and can be anticipated. However, when preventive countermeasures are needed, their effective implementation is multifaceted and depends on the provision of protective equipment and supplies, individuals’ understanding of the threat and attention to personal protective measures, treatment of malaria cases, and medical surveillance. The U.S. Armed Forces have long had policies and prescribed countermeasures effective against vector-borne diseases such as malaria, including chemoprophylactic drugs, permethrin-impregnated uniforms and bed nets, and topical insect repellents containing N,N-diethyl-meta-toluamide (DEET). When cases and outbreaks of malaria have occurred, they generally have been due to poor adherence to chemoprophylaxis and other personal preventive measures.7–10 MSMR malaria updates from the past 7 years documented that the annual case counts among service members after 2011 were the lowest in more than a decade.16 In particular, these updates showed that the numbers of cases associated with service in Afghanistan had decreased substantially in the past 7 years, presumably because of the dramatic reduction in the numbers of service members assigned there.17 This update for 2019 uses methods similar to those employed in previous analyses to describe the epidemiologic patterns of malaria incidence among service members in the active and reserve components of the U.S. Armed Forces.

METHODS

The surveillance period was 1 January 2010 through 31 December 2019. The surveillance population included Army, Navy, Air Force, and Marine Corps active and reserve component members of the U.S. Armed Forces. The records of the Defense Medical Surveillance System (DMSS) were searched to identify reportable medical events and hospitalizations (in military and non-military facilities) that included diagnoses of malaria. A case of malaria was defined as an individual with 1) a reportable medical event record of confirmed malaria; 2) a hospitalization record with a primary diagnosis of malaria; 3) a hospitalization record with a nonprimary diagnosis of malaria due to a specific Plasmodium species; 4) a hospitalization record with a nonprimary diagnosis of malaria plus a diagnosis of anemia, thrombocytopenia and related conditions, or malaria complicating pregnancy in any diagnostic position; 5) a hospitalization record with a nonprimary diagnosis of malaria plus diagnoses of signs or symptoms consistent with malaria (as listed in the Control of Communicable Diseases Manual, 18th edition18) in each diagnostic position antecedent to malaria; or 6) a positive malaria antigen test plus an outpatient record with a diagnosis of malaria in any diagnostic position within 30 days of the specimen collection date. The relevant International Classification of Diseases, 9th and 10th Revision (ICD-9 and ICD-10, respectively) codes are shown in Table 1. Laboratory data for malaria were provided by the Navy and Marine Corps Public Health Center.

This analysis allowed 1 episode of malaria per service member per 365-day period. When multiple records documented a single episode, the date of the earliest encounter was considered the date of clinical onset and the most specific diagnosis recorded within 30 days of the incident diagnosis was used to classify the Plasmodium species.

Presumed locations of malaria acquisition were estimated using a hierarchical algorithm: 1) cases diagnosed in a malarious country were considered acquired in that country, 2) reportable medical events that listed exposures to malaria endemic locations were considered acquired in those locations, 3) reportable medical events that did not list exposures to malaria endemic locations but were reported from installations in malaria endemic locations were considered acquired in those locations, 4) cases diagnosed among service members during or within 30 days of deployment or assignment to a malarious country were considered acquired in that country, and 5) cases diagnosed among service members who had been deployed or assigned to a malarious country within 2 years before diagnosis were considered acquired in those respective countries. All remaining cases were considered acquired in unknown locations.

RESULTS

In 2019, a total of 35 service members were diagnosed with or reported to have malaria (Table 2). That total was one of the lowest number of cases in any given year during the surveillance period and represents a 40.7% decrease from the 59 cases identified in 2018 (Figure 1). The percentage of 2019 cases of malaria caused by P. falciparum (54.3%) was the highest during any given year of the surveillance period. The highest previous annual percentage of P. falciparum was 46.8% in 2014. Of the 16 cases in 2019 not attributed to P. falciparum, 5 (14.3%) were identified as due to P. vivax and 11 (31.4%) were labeled as associated with other/unspecified types of malaria. The number of malaria cases caused by P. vivax in 2019 was one of the lowest observed during the 10-year surveillance period; the percentage of such cases remained one of the lowest. There was 1 case identified as having been caused by either P. malariae or P. ovale in 2019 (Figure 1).

Similar to 2018, the majority of U.S. military members diagnosed with malaria in 2019 were male (94.3%), active component members (85.7%), in the Army (82.9%), and in their 20s (54.3%) (Table 2).

Of the 35 malaria cases in 2019, slightly less than two-fifths of the infections were considered to have been acquired in Africa (37.1%; n=13); about one-third (31.4%; n=11) were attributed to Afghanistan; and about one-fourth (25.7%; n=9) could not be associated with a known, specific location. The remaining cases were attributed to Korea (5.7%; n=2); no cases were considered to have been acquired in South/Central America (Figure 2). Of the 13 malaria infections considered acquired in Africa in 2019, 4 were linked to Cameroon; 3 to Togo; 2 to Kenya; and 1 each to Djibouti, Liberia, Niger, and Nigeria (data not shown).

During 2019, malaria cases were diagnosed or reported from 17 different medical facilities in the U.S., Germany, Afghanistan, and Korea (Table 3). Almost one-third (31.4%; 11/35) of the total cases with a known location of diagnosis were reported from or diagnosed outside the U.S., which represents a slight increase from the 25.4% of malaria cases in this category in 2018. The largest number of malaria cases associated with a single medical facility during 2019 was 8 at the Evans Army Community Hospital in Fort Carson, CO.

In 2019, the percentage of malaria cases that were acquired in Africa (37.4%; n=13) increased from 2018 (25.4%) but was similar to the percentages in 2016 and 2017 (Figure 2). The percentage of Afghanistan-acquired cases (31.4%; n=11) in 2019 was similar to the percentage in 2018, which was the highest that it had been since 2013. The percentage of malaria cases acquired in Korea (5.7%; n=2) in 2019 was the lowest it had been since 2013 (Figure 2).

Between 2010 and 2019, the majority of malaria cases were diagnosed or reported during the 6 months from the middle of spring through the middle of autumn in the Northern Hemisphere (Figure 3). In 2019, 77.1% (27/35) of malaria cases among U.S. service members were diagnosed during May–October (data not shown). This proportion is similar to the 72.0% (432/600) of cases diagnosed during the same 6-month intervals over the entire 10-year surveillance period. During 2010–2019, the proportions of malaria cases diagnosed or reported during May–October varied by region of acquisition: Korea (91.9%; 57/62); Afghanistan (81.0%; 201/248); Africa (59.8%; 104/174); and South/Central America (50.0%; 3/6) (data not shown).

EDITORIAL COMMENT

MSMR annual reports on malaria incidence among all U.S. services began in 2007. The current report documents that the number of cases during 2019 decreased from 2018 and was one of the lowest of any of the previous years in the 2010–2019 surveillance period. The same number of malaria cases (n=35) was reported in 2017. Most of the marked decline in the past 8 years is attributable to the decrease in numbers of malaria cases associated with service in Afghanistan. The dominant factor in that trend has undoubtedly been the progressive withdrawal of U.S. forces from that country.

This report also documents the fluctuating incidence of acquisition of malaria in Africa and Korea among U.S. military members during the past decade. Although the predominant species of malaria in Korea and Afghanistan has been P. vivax, the more dangerous P. falciparum species is of primary concern in Africa. This report documents that the 2019 percentage of cases caused by P. falciparum was the highest of any year of the surveillance period. The planning and execution of military operations on that continent must incorporate actions to counter the threat of infection by that potentially deadly parasite wherever it is endemic. The 2014–2015 employment of U.S. service members to aid in the response to the Ebola virus outbreak in West Africa is an example of an operation where the risk of P. falciparum malaria was significant.15,19 The finding that P. falciparum malaria was diagnosed in more than one-half of the cases in 2019 further underscores the need for continued emphasis on prevention of this disease, given its potential severity and risk of death. Moreover, a recent article noted the possibility of false negative results for P. falciparum on the rapid diagnostic tests favored by units in resource limited or austere locations.20 Although more research is needed, commanders and unit leaders may need to be especially vigilant with forces that are far forward.

The observations about the seasonality of diagnoses of malaria are compatible with the presumption that the risk of acquiring and developing symptoms of malaria in a temperate climatic zone of the Northern Hemisphere would be greatest during May–October. Given the typical incubation periods of malaria infection (approximately 9–14 days for P. falciparum, 12–18 days for P. vivax and P. ovale, and 18–40 days for P. malariae)18 and the seasonal disappearance of biting mosquitoes during the winter, most malaria acquired in Korea and Afghanistan would be expected to cause symptoms during the warmer months of the year. However, it should be noted that studies of P. vivax malaria in Korea have found that the time between primary infection and clinical illness among different P. vivax strains ranges between 8 days and 8–13 months and that as many as 40–50% of infected individuals may not manifest the symptoms of their primary illness until 6–11 months after infection.21,22 Klein and colleagues recently reported a cluster of 11 U.S. soldiers with P. vivax malaria who were likely infected at a training area located near the southern border of the demilitarized zone in 2015.23 Nine of the malaria cases developed their first symptoms of infection 9 or more months after exposure and after their departure from Korea.23 Transmission of malaria in tropical regions such as sub-Saharan Africa is less subject to the limitations of the seasons as in temperate climates but depends more on other factors affecting mosquito breeding, such as the timing of the rainy season and altitude (below 2,000 meters).24

There are significant limitations to this report that should be considered when interpreting the findings. For example, the ascertainment of malaria cases is likely incomplete; some cases treated in deployed or non-U.S. military medical facilities may not have been reported or otherwise ascertained at the time of this analysis. Furthermore, it should be noted that the medical records of the DMSS do not contain medical data from military treatment facilities that are using the new electronic health records of MHS GENESIS, which was implemented at different sites throughout 2017. These sites include Naval Hospital Oak Harbor, Naval Hospital Bremerton, Air Force Medical Services Fairchild, and Madigan Army Medical Center. Therefore, the medical encounter data for individuals seeking care at any of these facilities were not captured in this analysis.

Diagnoses of malaria that were documented only in outpatient settings without records of a positive malaria antigen test and that were not reported as notifiable events were not included as cases. Also, the locations of infection acquisitions were estimated from reported relevant information. Some cases had reported exposures in multiple malarious areas, and others had no relevant exposure information. Personal travel to or military activities in malaria-endemic countries were not accounted for unless specified in notifiable event reports.

As in prior years, in 2019 most malaria cases among U.S. military members were treated at medical facilities remote from malaria endemic areas. Providers of acute medical care to service members (in both garrison and deployed settings) should be knowledgeable of and vigilant for the early clinical manifestations of malaria among service members who are or were recently in malaria-endemic areas. Care providers should also be capable of diagnosing malaria (or have access to a clinical laboratory that is proficient in malaria diagnosis) and initiating treatment (particularly when P. falciparum malaria is clinically suspected).

Continued emphasis on adherence to standard malaria prevention protocols is warranted for all military members at risk of malaria. Personal protective measures against malaria include the proper wear of permethrin-treated uniforms and the use of permethrin-treated bed nets; the topical use of military-issued, DEET-containing insect repellent; and compliance with prescribed chemoprophylactic drugs before, during, and after times of exposure in malarious areas. Current Department of Defense guidance about medications for prophylaxis of malaria summarizes the roles of chloroquine, atovaquone-proguanil, doxycycline, mefloquine, primaquine, and tafenoquine.25,26

Acknowledgments: The authors thank the Navy and Marine Corps Public Health Center, Portsmouth, VA, for providing laboratory data for this analysis.

REFERENCES

1. World Health Organization. World Malaria Report 2019. WHO, Geneva 2019. https://www.who.int/publications-detail/world-malaria-report-2019. Accessed 17 January 2019.
2. Mace KE, Arguin PM, Lucci NW, Tan KR. Malaria Surveillance—United States, 2016. MMWR Surveill Summ. 2019;68(5):1–35.
3. U.S. Army Center for Health Promotion and Preventive Medicine. Malaria, U.S. Army, 1998. MSMR. 1999;5(1):2–3.
4. Gupta RK, Gambel JM, Schiefer BA. Personal protection measures against arthropods. In: Kelley PW, ed. Military Preventive Medicine: Mobilization and Deployment, Volume 1. Falls Church, VA: Office of the Surgeon General, Department of the Army; 2003:503–521.
5. Ognibene AJ, Barrett O. Malaria: introduction and background. In: Ognibene AJ, Barrett O, eds. Internal Medicine in Vietnam Vol II: General Medicine and Infectious Diseases. Washington, DC: Office of the Surgeon General, Center of Military History; 1982:271–278.
6. Shanks GD, Karwacki JJ. Malaria as a military factor in Southeast Asia. Mil Med. 1991;156(12):684–668.
7. Kotwal RS, Wenzel RB, Sterling RA, et al. An outbreak of malaria in U.S. Army Rangers returning from Afghanistan. JAMA. 2005;293(2):212–216.
8. Whitman TJ, Coyne PE, Magill AJ, et al. An outbreak of Plasmodium falciparum malaria in U.S. Marines deployed to Liberia. Am J Trop Med Hyg. 2010;83(2):258–265.
9. Centers for Disease Control and Prevention. Malaria acquired in Haiti–2010. MMWR. 2010;59(8):217–218.
10. Shaha DP, Pacha LA, Garges EC, Scoville SL, Mancuso JD. Confirmed malaria cases among active component U.S. Army personnel, January–September 2012. MSMR. 2013;20(1):6–9.
11. Lee JS, Lee WJ, Cho SH, Ree H. Outbreak of vivax malaria in areas adjacent to the demilitarized zone, South Korea, 1998. Am J Trop Med Hyg. 2002;66(1):13–17.
12. Armed Forces Health Surveillance Center (Provisional). Korea-acquired malaria, U.S. Armed Forces, January 1998–October 2007. MSMR. 2007;14(8):2–5.
13. Ciminera P, Brundage J. Malaria in U.S. military forces: a description of deployment exposures from 2003 through 2005. Am J Trop Med Hyg. 2007;76(2):275–279.
14. Armed Forces Health Surveillance Center. Malaria among deployers to Haiti, U.S. Armed Forces, 13 January–30 June 2010. MSMR. 2010;17(8):11.
15. Woods M. Biggest threat to U.S. troops in Liberia is malaria, not Ebola. https://www.army.mil/article/139340/biggest_threat_to_us_troops_in_liberia_is_malaria_not_ebola. Published 4 December 2014. Accessed 17 January 2020.
16. Armed Forces Health Surveillance Center. Update: Malaria, U.S. Armed Forces, 2012. MSMR. 2013;20(1):2–5.
17. Armed Forces Health Surveillance Branch. Update: Malaria, U.S. Armed Forces, 2018. MSMR. 2019;26(2):2–7.
18. Heymann DL, ed. Control of Communicable Diseases Manual. 18th ed. Washington, DC: American Public Health Association; 2004.
19. Mace KE, Arguin PM, Tan KR. Malaria Surveillance—United States, 2015. MMWR Surveill Summ. 2018;67(7):1–28.
20. Forshey BM, Morton L, Martin N, et al. Plasmodium falciparum rapid test failures threaten diagnosis and treatment of U.S. military personnel. Mil Med. 2020;185(1–2):e1–e4.
21. White, NJ. Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J. 2011;10:297.
22. Distelhorst JT, Marcum RE, Klein TA, Kim HC, Lee WJ. Report of two cases of vivax malaria in U.S. soldiers and a review of malaria in the Republic of Korea. MSMR. 2014;21(1):8–14.
23. Klein TA, Seyoum B, Forshey BM, et al. Cluster of vivax malaria in U.S. soldiers training near the demilitarized zone, Republic of Korea during 2015. MSMR. 2018;25(11):4–9.
24. Fairhurst RM, Wellems TE. Plasmodium species (malaria). In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier; 2010.
25. Assistant Secretary of Defense for Health Affairs. Guidance on Medications for Prophylaxis of Malaria. HA-Policy 13-002. 15 April 2013. 
26. Defense Health Agency. Procedural Instruction 6490.03. Deployment Health Procedures. 17 December 2019.

Numbers of malaria cases, by Plasmodium species and calendar year of diagnosis or report, active and reserve components, U.S. Armed Forces, 2010–2019 

Annual numbers of malaria cases, by location of acquisition, U.S. Armed Forces, 2010–2019

Cumulative numbers of diagnoses and reported cases of malaria, by month of clinical presentation or diagnosis, U.S. Armed Forces, January 2010–December 2019

Malaria cases by Plasmodium species and selected demographic characteristics, U.S. Armed Forces, 2019

 Number of malaria cases, by geographical locations of diagnosis or report and presumed location of acquisition, active and reserve components, U.S. Armed Forces, 2019

 

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Infographic
2/5/2018
On 29 July 2016, the U.S. Coast Guard Training Center Cape May (TCCM), NJ, identified an increase in febrile respiratory illness (FRI) among recruits who were unvaccinated against seasonal influenza as a result of the annual vaccine’s expiration. This report characterizes the outbreak and containment measures implemented at TCCM during the outbreak period. In 2016, respiratory infections affected more than 250,000 U.S. service members and comprised approximately 22% of medical encounters among military recruit populations – who are highly susceptible to respiratory infections. Seasonal influenza and rhinovirus are two of the leading respiratory pathogens. During the Surveillance Period: 115 recruits reported respiratory infection symptoms. Pie chart 1 shows the following data: •	41 (35.7%) suspected cases •	74 (64.3%) confirmed cases Among confirmed cases, lab specimens tested positive for: •	Influenza A 34 (45.9%) •	Rhinovirus 28 (37.8%) •	Influenza A and rhinovirus co-infection 11 (14.9%) •	Rhinovirus and adenovirus co-infection 1 (1.4%) Data above depicted in pie chart 2. •	24 July – 6 August, Influenza predominated •	7 August – 20 August, Rhinovirus predominated Although the outbreak significantly affected operations at TCCM, a timely and comprehensive response resulted in containment of the outbreak within 5 weeks. Key Factor for Outbreak Control •	Rapid detection through FRI sentinel surveillance •	Quick decision-making •	Streamlined response by using a single chain of command •	Rapid implementation of both nonpharmaceutical and pharmaceutical interventions Access the full report in the January 2018 MSMR (Vol. 25, No. 1). Go to: www.Health.mil/MSMR

This report characterizes the outbreak and containment measures implemented at the U.S. Coast Guard Training Center Cape May (TCCM), New Jersey, during a July 24 – August 21, 2016 outbreak period.

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Health Readiness | Medical Surveillance Monthly Report | Integrated Biosurveillance | Influenza Summary and Reports

Seizures among Active Component service members, U.S. Armed Forces, 2007 – 2016

Infographic
1/25/2018
This retrospective study estimated the rates of seizures diagnosed among deployed and non-deployed service members to identify factors associated with seizures and determine if seizure rates differed in deployment settings. It also attempted to evaluate the associations between seizures, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) by assessing correlations between the incidence rates of seizures and prior diagnoses of TBI and PTSD. Seizures have been defined as paroxysmal neurologic episodes caused by abnormal neuronal activity in the brain. Approximately one in 10 individuals will experience a seizure in their lifetime. Line graph 1: Annual crude incidence rates of seizures among non-deployed service members, active component, U.S. Armed Forces data •	A total of 16,257 seizure events of all types were identified among non-deployed service members during the 10-year surveillance period. •	The overall incidence rate was 12.9 seizures per 10,000 person-years (p-yrs.) •	There was a decrease in the rate of seizures diagnosed in the active component of the military during the 10-year period. Rates reached their lowest point in 2015 – 9.0 seizures per 10,000 p-yrs. •	Annual rates were markedly higher among service members with recent PTSD and TBI diagnoses, and among those with prior seizure diagnoses. Line graph 2: Annual crude incidence rates of seizures by traumatic brain injury (TBI) and recent post-traumatic stress disorder (PTSD) diagnosis among non-deployed active component service members, U.S. Armed Forces •	For service members who had received both TBI and PTSD diagnoses, seizure rates among the deployed and the non-deployed were two and three times the rates among those with only one of those diagnoses, respectively. •	Rates of seizures tended to be higher among service members who were: in the Army or Marine Corps, Female, African American, Younger than age 30, Veterans of no more than one previous deployment, and in the occupations of combat arms, armor, or healthcare Line graph 3: Annual crude incidence rates of seizures diagnosed among service members deployed to Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn, U.S. Armed Forces, 2008 – 2016  •	A total of 814 cases of seizures were identified during deployment to operations in Iraq and Afghanistan during the 9-year surveillance period (2008 – 2016). •	For deployed service members, the overall incidence rate was 9.1 seizures per 10,000 p-yrs. •	Having either a TBI or recent PTSD diagnosis alone was associated with a 3-to 4-fold increase in the rate of seizures. •	Only 19 cases of seizures were diagnosed among deployed individuals with a recent PTSD diagnosis during the 9-year surveillance period. •	Overall incidence rates among deployed service members were highest for those in the Army, females, those younger than age 25, junior enlisted, and in healthcare occupations. Access the full report in the December 2017 MSMR (Vol. 24, No. 12). Go to www.Health.mil/MSMR

This infographic documents a retrospective study which estimated the rates of seizures diagnosed among deployed and non-deployed service members to identify factors associated with seizures and determine if seizure rates differed in deployment settings. The study also evaluated the associations between seizures, traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) by assessing correlations between the incidence rates of seizures and prior diagnoses of TBI and PTSD.

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Health Readiness | Posttraumatic Stress Disorder | Armed Forces Health Surveillance Division | Medical Surveillance Monthly Report

Insomnia and motor vehicle accident-related injuries, Active Component, U.S. Armed Forces, 2007 – 2016

Infographic
1/25/2018
Insomnia is the most common sleep disorder in adults and its incidence in the U.S. Armed Forces is increasing. A potential consequence of inadequate sleep is increased risk of motor vehicle accidents (MVAs). MVAs are the leading cause of peacetime deaths and a major cause of non-fatal injuries in the U.S. military members. To examine the relationship between insomnia and motor vehicle accident-related injuries (MVAs) in the U.S. military, this retrospective cohort study compared 2007 – 2016 incidence rates of MVA-related injuries between service members with diagnosed insomnia and service members without a diagnosis of insomnia. After adjustment for multiple covariates, during 2007 – 2016, active component service members with insomnia had more than double the rate of MVA-related injuries, compared to service members without insomnia. Findings:  •	Line graph shows the annual rates of motor vehicle accident-related injuries, active component service members with and without diagnoses of insomnia, U.S. Armed Forces, 2007 – 2016  •	Annual rates of MVA-related injuries were highest in the insomnia cohort in 2007 and 2008, and lowest in 2016 •	There were 5,587 cases of MVA-related injuries in the two cohorts during the surveillance period. •	Pie chart displays the following data: 1,738 (31.1%) in the unexposed cohort and 3,849 (68.9%) in the insomnia cohort The highest overall crude rates of MVA-related injuries were seen in service members who were: •	Less than 25 years old •	Junior enlisted rank/grade •	Armor/transport occupation •	 •	With a history of mental health diagnosis •	With a history of alcohol-related disorders Access the full report in the December 2017 (Vol. 24, No. 12). Go to www.Health.mil/MSMR Image displays a motor vehicle accident.

To examine the relationship between insomnia and motor vehicle accident-related injuries (MVAs) in the U.S. military, this retrospective cohort study compared 2007 – 2016 incidence rates of MVA-related injuries between service members with diagnosed insomnia and service members without a diagnosis of insomnia.

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Armed Forces Health Surveillance Division | Health Readiness | Medical Surveillance Monthly Report
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