Skip main navigation

Military Health System

Clear Your Browser Cache

This website has recently undergone changes. Users finding unexpected concerns may care to clear their browser's cache to ensure a seamless experience.

Traumatic Brain Injury Rapid Test Will Aid Field Diagnosis and Help Prioritize Treatment

Image of Traumatic Brain Injury Rapid Test Will Aid Field Diagnosis and Help Prioritize Treatment. U.S. Army Sgt. Raymond Calzada, a medical laboratory specialist with the First Medical Brigade, waits for test results from the Analyzer Traumatic Brain Injury (ATBI) system as part of a simulated casualty scenario during a combat support training exercise at Fort Hunter Liggett, California, on June 18, 2023. The exercise was designed in part to get feedback from end users of the portable, deployable TBI biomarker assay system. On April 1, 2024, USAMMDA and manufacturer Abbott announced U.S. Food and Drug Administration clearance of the whole blood TBI cartridge for use on the device. (U.S. Army courtesy photo)

A new rapid test produces lab quality results using whole blood to identify biomarkers associated with mild traumatic brain injury, otherwise known as concussion.

The results could help forward-deployed medics and health care providers at battalion aid stations and field hospitals decide which wounded service members they need to treat first and who needs to be evacuated from the field.

Having a simple and fieldable test for mild TBI is critical to providing timelier high-quality care for the Military Health System. More than 492,000 U.S. service members worldwide sustained a TBI resulting from military training, deployment, or day-to-day activities—such as sporting events—from November 2000–2023, according to statistics compiled by the Defense Health Agency Traumatic Brain Injury Center of Excellence and reported in the TBICoE 2023 annual report released on March 29, 2024.

Improving TBI Testing in Future Conflicts

The test, cleared for use by the U.S. Food and Drug Administration in March 2024, is one of the most significant steps forward in the care of TBI patients in the past 20 years, according to neuroscientist U.S. Army Lt. Col. (Dr.) Bradley Dengler, director of the Military Traumatic Brain Injury Initiative at the Uniformed Services University in Bethesda, Maryland.

Previous tests to help diagnose concussion or more severe TBI were cleared by FDA in early 2021 only for use with blood plasma or serum. This required samples to be sent to a laboratory for processing and results.

The new test, which takes only 15 minutes for results and is run on a portable device, also can be used to evaluate patients up to 24 hours after injury, a significant improvement from previously available tests. The device therefore could aid in decisions on priority evacuations from forward deployments in a future conflict where rapid evacuation (the “golden hour”) is not possible.

“Given the large numbers of expected casualties with all severities of traumatic brain injury in future large-scale combat operations, this test can help maintain combat power far forward by helping to eliminate unnecessary evacuations,” Dengler said.

“Additionally, and just as important, given the limited number of neurosurgeons available in-theater, ongoing research demonstrates that a future version of this test could be used to triage more severely injured patients, as the blood biomarker elevations correlate with the severity of their intracranial injuries,” Dengler commented. “This can help get the most severely injured service members to neurosurgeons faster and ultimately save lives.”

MTBI2 is the only military health organization that conducts clinical trials and translational research spanning all TBIs—mild to severe—and focuses on acute and subacute phases. Dengler also serves as the neurosurgical consultant to the U.S. Army surgeon general.

U.S. Army Plays Key Development Role

The U.S. Army Medical Research and Development Command, headquartered at Fort Detrick in Frederick, Maryland, has been dedicated to developing a solution for detecting and evaluating TBIs for more than two decades.

The new diagnostic method will prevent unnecessary medical evacuations and improve TBI case management in the field since not all patients will require head CT scans, said U.S. Army Col. Andy Nuce, commander of the U.S. Army Medical Materiel Development Activity, part of USAMRDC.

In July 2023, the technology was tested in simulated battle conditions during a soldier “touchpoint” as part of the Global Medic combat support training exercise at the U.S. Army’s Fort Hunter Liggett, California, which is known as the military's premier total force training center.

Program experts from USAMMDA’s Warfighter Brain Health Project Management Office and Warfighter Deployed Medical Systems Project Management Office joined leaders with USAMRDC and the Medical Capability Development Integration Directorate to participate in the field trial. Subject matter experts from USAMMDA, the Combat Casualty Care Research Program, and the Walter Reed Army Institute of Research also participated in the program’s development.

"TBIs are a major concern for warfighter health, readiness, and resiliency,” said U.S. Army Brig. Gen. (Dr.) Edward H. Bailey, commanding general of USAMRDC. “This milestone demonstrates how Army medical developers can partner with industry to deliver solutions for frontline medical personnel caring for our injured service members.”

U.S. Army officials, in partnership with medical device manufacturer Abbott, jointly announced April 1, 2024, that the company’s i-STAT® TBI whole blood cartridge had received FDA marketing clearance. Abbott developed the blood test in collaboration with USAMMDA.

The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) research team was the first to demonstrate how the TBI blood test could be used to benefit TBI patients in clinical care. Spanning the USAMRDC and broader Department of Defense community, these multifaceted teams were unified by the common goal of developing a TBI product that meets the needs of the warfighter.

“During future large-scale combat operations, enemy weapons and exposure to blast or concussive events will present challenges to frontline medical providers,” USAMMDA’s Nuce said. “We are constantly working to investigate, develop, and field modern medical solutions to protect the warfighters of 2030, 2040, and beyond.”

USAMMDA takes promising medical technology from DHA, industry, and academia to U.S. forces. It develops critical drugs, vaccines, biologics, devices, and medical support equipment, from the testing required for FDA approval or licensing to field trials and sustainment of the finished product.

You also may be interested in...

Article Around MHS
Apr 26, 2024

Researchers and Guard Physicians Set Their Sights on Mitigating the Impact of Blast Exposures

Military personnel and civilian researchers at a training at Fort McCoy

Red Arrow soldiers from the 1-120th Field Artillery Battalion and 1-105th Cavalry Squadron were visited by a team of civilian researchers and Wisconsin National Guard surgeons on April 9, 2024, during their training at Fort McCoy, Wisconsin, to discuss a study to measure blast exposure and evaluate associated effects among soldiers during routine ...

Article Around MHS
Feb 5, 2024

U.S. Army Medical Research & Development Command Supports Development of Blast Injury Prevention Standard

 Researchers from the Walter Reed Army Institute of Research used data collected during live fire training exercises to create accurate 3D simulations of blast overpressure exposures on virtual weapons crews to help training range managers, range safety officers and instructors position personnel to minimize their exposure to shock waves created by the firing of heavy weapons. The color coding indicates the blast pressure intensity as the wave expands and dissipates.

A new tool being developed by the U.S. Army Medical Research and Development Command’s DOD Blast Injury Research Coordinating Office will help Service Members protect themselves from the effects of high-pressure shock waves created by heavy weapons when they are fired during training.

Article Around MHS
Dec 5, 2023

When Your Spouse Has a Traumatic Brain Injury

Lorie Falaminiano, an MRI technologist assigned to Naval Medical Center San Diego (NMCSD), conducts an MRI scan of a patient's brain at the NMCSD hospital.

As a spouse of a service member who has suffered a traumatic brain injury, you may be experiencing a range of emotions. It is important to allow yourself to feel every emotion that surfaces and attend to your own needs. Here are some strategies to consider as you prepare to take on your new role as a caregiver to your spouse.

Article Around MHS
Dec 1, 2023

Neuropsychiatry/TBI Unit at Walter Reed Unique in DOD

Dr. David Williamson, medical director for the Neuropsychiatry/Traumatic Brain Injury unit at Walter Reed National Military Medical Center and his staff are breaking new ground in identifying and treating TBI and behavioral health challenges.  (courtesy photo)

Walter Reed National Military Medical Center (WRNMMC) has the Department of Defense’s only Neuropsychiatry/Traumatic Brain Injury (TBI) Unit. It serves as a referral program for Military Health System (MHS) beneficiaries throughout the defense department, as well as for congressional members needing care for the impacts of head injuries and other ...

Article Around MHS
Dec 1, 2023

Walter Reed's National Intrepid Center of Excellence Scientists to Present New TBI Battlefield Biomarkers Research During 2023 MHSRS

Dr. Ping-Hong Yeh all smiles at Walter Reed in preparation for presenting new biomarkers TBI research at 2023 MHSRS. (Photo Credit: Ricardo Reyesguevarra)

Walter Reed National Military Medical Center is pleased to announce that researchers from the National Intrepid Center of Excellence (NICoE) will present a groundbreaking study on diagnosing traumatic brain injuries (TBIs) during the 2023 Military Health System Research Symposium (MHSRS) taking place Aug. 14-17, 2023 at the Gaylord Palms Resort and ...

Article Around MHS
Dec 1, 2023

Be a 'Brain Warrior' and Protect Yours

The National Intrepid Center of Excellence (NICoE) at Walter Reed National Military Medical Center (WRNMMC), along with the entire Military Health System (MHS), places emphasize on protecting the brain, as well as seeking treatment for brain injuries, every day.  (courtesy photo)

March is annually observed as Brain Injury Awareness Month (BIAM), and the National Intrepid Center of Excellence at Walter Reed National Military Medical Center, along with the entire Military Health System (MHS), places emphasize on protecting the brain, as well as seeking treatment for brain injuries, every day.

Article Around MHS
Dec 1, 2023

U.S. Army Medical Materiel Development Activity Pharmacist Excels as Warfighter Brain Health Product Manager, Mom, and Leader

U.S. Army Maj. Dana Bal tests a brain hemorrhage detection device during familiarization training at the headquarters of the U.S. Army Medical Materiel Development Activity, Fort Detrick, Md., Dec. 28, 2022. Bal serves as part of the Program Management-Acquisition Internship Program and as assistant product manager with USAMMDA’s Warfighter Brain Health Project Management Office. (U.S. Army Photo by T. T. Parish)

Aiming to join the Army Medical Service Corps as a pharmacist, Dana Bal graduated and earned her commission in 2008 before being awarded a Health Professions Scholarship Program (HPSP) educational delay to complete pharmacy school. Find out why Bal credits the Army for her success as a Warfighter Brain Health Product Manager, a mom, and a leader.

Skip subpage navigation
Refine your search
Last Updated: May 24, 2024
Follow us on Instagram Follow us on LinkedIn Follow us on Facebook Follow us on X Follow us on YouTube Sign up on GovDelivery