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Case Report: Hansen’s Disease in an Active Duty Soldier Presenting with Type 1 Reversal Reaction

Ulcer along the interspace between the patient’s right index and middle fingers. Photograph courtesy of Brooke Army Medical Center Medical Photography. Ulcer along the interspace between the patient’s right index and middle fingers. Photograph
courtesy of Brooke Army Medical Center Medical Photography.

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ABSTRACT

Leprosy, or Hansen’s disease (HD), is caused by the bacterium Mycobacterium leprae and is a significant cause of morbidity worldwide. Clinical manifestations range from isolated skin rash to severe peripheral neuropathy. Treatment involves a prolonged course of multiple antimicrobials. Although rare in the U.S., with only 168 new cases reported in 2016, HD remains a prevalent disease throughout the world, with 214,783 new cases worldwide that same year.1 It remains clinically relevant for service members born in and deployed to endemic regions. This report describes a case of HD diagnosed in an active duty soldier born and raised in Micronesia, a highly endemic region.

CASE REPORT

In May 2018, a 21-year-old male soldier presented with right hand swelling and ulcer formation along the interspace between his index and middle fingers while he was deployed to Eastern Europe (Figure 1). He first developed a blister at that site after washing a tank several days earlier, and it subsequently progressed to an ulcer. The ulcer was initially assessed as a third-degree burn, and he was transferred to Brooke Army Medical Center (Joint Base San Antonio-Fort Sam Houston, TX) for management on 11 May 2018. At that time, the patient denied any pain but described gradual loss of sensation to his right hand dating back to January 2018. The patient had been otherwise healthy except for a right hand burn injury during basic training in early 2017, which had completely healed without complications. He denied any close contacts with Hansen's disease (HD). The patient had enlisted in the Army in January 2017 from the Federated States of Micronesia and completed initial entry training in June 2017 at Fort Benning, GA. He completed advanced individual training at Fort Riley, KS, and then was deployed to Europe in November 2017.

In May 2018, the patient successfully underwent full-thickness skin graft of his ulceration but continued to experience edema and eventually lost intrinsic motor function of his right hand. He remained at Fort Sam Houston, where a nerve conduction study in July 2018 revealed severe median, ulnar, and radial neuropathies in the right forearm. Around that time, the patient noticed eruption of annular, hyperpigmented, erythematous plaques on his right medial arm, which spread to his bilateral limbs and trunk (Figures 2a, 2b). These symptoms coincided with new edema and numbness involving his left hand. In September 2018, magnetic resonance imaging revealed perineural edema involving nerve groups of his distal right arm (Figure 3a, 3b). The patient was referred to dermatology, where examination noted thickening of peripheral nerves, including the greater auricular nerve (Figure 4); a clinical diagnosis of HD was made. Skin biopsy showed tuberculoid granulomas extending along adnexal structures and nerves (Figure 5a, 5b). Fite staining was negative for acid-fast organisms. Polymerase chain reaction testing at the National Hansen’s Disease Program (NHDP) was also negative for Mycobacterium leprae. Given his histopathology, edema, and rapid progression of neurologic impairment, the patient was diagnosed with paucibacillary leprosy complicated by type 1 reversal reaction. In consultation with the NHDP, the patient was started on clarithromycin 500 mg daily and minocycline 100 mg daily in October 2018. Prednisone 60 mg daily was started for the patient’s type 1 reversal reaction and neuropathy. Steroids were tapered over the ensuing 6 months, while methotrexate 12.5 mg weekly was added as a steroid-sparing agent.

At follow-up in December 2018, the patient showed improvement in the appearance of his skin lesions and the edema in both hands, with some improvement in motor and sensory exam. At follow-up in May 2019, he remained on clarithromycin, minocycline, and methotrexate. He showed further improvement in the appearance of his skin lesions. However, he continued to have persistent right hand weakness and persistent left ulnar neuropathy. He was referred to the medical evaluation board and was discharged from the Army in August 2019.

EDITORIAL COMMENT

HD is caused by M. leprae. While the disease is endemic in the southern U.S., the majority of cases found here are diagnosed in individuals born outside of the U.S., where exposure is thought to have occurred.2 The Federated States of Micronesia has a high prevalence of HD, and immigrants from Oceanic countries have the highest rates of diagnosis in the U.S.2,3

Skin lesions and peripheral nerve damage are hallmarks of HD. The diagnosis can be made clinically, though histopathology is the gold standard.4 Complications of HD include type 1 reversal reactions, which are associated with increased cell-mediated immune response to M. leprae, leading to increased edema and swelling of peripheral nerves and increased erythema of existing skin lesions.4 This patient’s presenting symptoms of hand edema and ulceration (Figure 1) represented a type 1 reversal reaction that led to significant neurologic impairment.

The treatment of HD typically involves dapsone and rifampin, with or without clofazimine, based on the disease classification.5 Minocycline and clarithromycin are bactericidal against M. leprae6 and have been used as alternative treatments when first-line agents cannot be used because of drug intolerance or, as in this case, drug interactions between rifampin and prednisone.4 The treatment of type 1 reversal reaction typically involves corticosteroids, though the overall efficacy and duration of therapy remain uncertain.7,8

The military provides a unique environment for exposure, as soldiers are often deployed into endemic areas. However, reported cases of HD among U.S. military personnel are rare. The first such reported cases occurred in the Spanish-American War (1898) despite prior conflicts in endemic areas.9,10 Among the 323 reported cases of leprosy in veterans between 1920 and 1968, less than 80 were thought to be service related.9 Among those cases not involving infections after receiving tattoos, only 2 cases involved service members whose length of exposure was reported as less than 1 year.9,10 The Vietnam War brought U.S. soldiers into combat in endemic areas of Southeast Asia, but there are even fewer reported cases among veterans of this conflict, with at least 3 service-related cases.11–13 The low number of cases likely reflected decreased exposure time due to shorter deployments and the use of dapsone for malaria prophylaxis.14 Since the start of the current Global War on Terrorism, there have been at least 6 published cases of HD among active duty U.S. military members, the majority of which were not service related.15–18 Five of the 6 published cases involved service members from Micronesia. (Currently, there are 2 other active cases of HD being treated in service members in conjunction with the NHDP.) In a case series of 3 active duty soldiers from Micronesia with HD, the average time to diagnosis was 8 months.15 This observation illustrates that HD’s indolent course of skin lesions and neurologic deficits can lead to a delay in diagnosis.19 Given the potential morbidity associated with delayed diagnosis, providers should consider HD in a patient from an endemic region with rash and neuropathy.

There have been no published reports among U.S. troops of HD secondary to exposure to other infected service members. However, there have been reported cases of family members contracting HD from service members.9 Such examples indicate that prolonged, close exposure to an infected individual or prolonged travel to endemic countries is needed for infection with HD.

Before effective therapies were widely available, a diagnosis of HD resulted in discharge from the U.S. Army.9 However, currently, if the HD responds to treatment and does not lead to physical limitations, affected service members may be retained.20

In summary, HD is rare in the U.S. military and its veterans. However, because of the potential significant morbidity associated with delayed diagnosis and treatment of HD, this condition should be considered in patients presenting with skin lesions and peripheral neuropathy, especially if the patients are from HD-endemic regions.

Author affiliations: Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, TX (MAJ Jansen and Maj Lindholm); National Hansen’s Disease Program, Baton Rouge, LA (Dr. Stryjewska); Uniformed Services University of the Health Sciences, Bethesda, MD (Maj Lindholm); Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio-Lackland, TX (Maj Bandino and Capt Durso)

Disclaimer: The contents of this publication are the sole responsibility of the authors and do not necessarily reflect the views or policies of the Uniformed Services University of the Health Sciences, Brooke Army Medical Center, Wilford Hall Ambulatory Surgical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, the Department of Defense, or the U.S. Government. Mention of trade name, commercial products, or organizations does not imply endorsement by the U.S. Government. The authors are employees of the U.S. Government. This work was prepared as part of their official duties. Title 17 U.S.C. §105 provides that copyright protection under this title is not available for any work of the U.S. Government. Title 17 U.S.C. §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.

REFERENCES

1. World Health Organization. Global leprosy update, 2016: accelerating reduction of disease burden. Wkly Epidemiol Rec. 2017;92(35):501–519.

2. Nolen L, Haberling D, Scollard D, et al. Incidence of Hansen's disease—United States, 1994–2011. MMWR Morb Mortal Wkly Rep. 2014;63(43):969–972.

3. Woodall P, Scollard D, Rajan L. Hansen disease among Micronesian and Marshallese persons living in the United States. Emerg Infect Dis. 2011;17(7):1202–1208.

4. Britton WJ, Lockwood DN. Leprosy. Lancet. 2004;363(9416):1209–1219.

5. Moschella SL. An update on the diagnosis and treatment of leprosy. J Am Acad Dermatol. 2004;51(3):417–426.

6. Ji B, Jamet P, Perani EG, Bobin P, Grosset JH. Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. J Infect Dis. 1993;168(1):188–190.

7. Van Veen NH, Nicholls PG, Smith WC, Richardus JH. Corticosteroids for treating nerve damage in leprosy. Cochrane Database Syst Rev. 2016;(5):CD005491.

8. Walker SL, Lockwood DN. Leprosy type 1 (reversal) reactions and their management. Lepr Rev. 2008;79(4):372–386.

9. Brubaker ML, Binford CH, Trautman JR. Occurrence of leprosy in U.S. veterans after service in endemic areas abroad. Public Health Rep. 1969;84(12):1051–1058.

10. Aycock WL, Gordon JE. Leprosy in veterans of American wars. Am J Med Sci. 1947;214(3):329–339.

11. Medford FE. Leprosy in Vietnam veterans. Arch Intern Med. 1974;134(2):373.

12. Rose HD. Letter: Leprosy in Vietnam returnees. JAMA.1974;230(10):1388.

13. Kivirand AI, Price PH. Leprosy in Vietnam veteran. Arch Pathol Lab Med. 1979;103(7):367.

14. Enna CD, Trautman JR. Leprosy in the military services. Mil Med. 1969;134(12):1423–1426.

15. Hartzell JD, Zapor M, Peng S, Straight T. Leprosy: a case series and review. South Med J. 2004;97(12):1252–1256.

16. Berjohn CM, DuPlessis CA, Tieu K, Maves RC. Multibacillary leprosy in an active duty military member. Emerg Infect Dis. 2015;21(6):1077–1078.

17. Bossalini JP, Bandino JP, Miletta NR. Delayed diagnosis of leprosy in a Micronesian soldier—case report. Mil Med. 2019;184(9/10):561–564.

18. Wellington T, Schofield C. Late-onset ulnar neuritis following treatment of lepromatous leprosy infection. PLoS Negl Trop Dis. 2019;13(8):e0007684.

19. Chad DA, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 1-2004. A 49-year-old woman with asymmetric painful neuropathy. N Engl J Med. 2004;350(2):166–176.

20. Headquarters, Department of the Army. Army Regulation 40-501. Medical Services. Standards of Medical Fitness. 27 June 2019.

Ulcer along the interspace between the patient’s right index and middle fingers. Photograph courtesy of Brooke Army Medical Center Medical Photography

Multiple, large, irregular, welldemarcated, scaly, erythematous plaques on the left arm. These lesions were noted to have diminished sensation compared to surrounding normal skin. Photograph courtesy of Brooke Army Medical Center Medical Photography.

Multiple, large, well-demarcated, annular, hyperpigmented, scaly plaques with relative central clearing on the left leg. These lesions were noted to have diminished sensation compared to surrounding normal skin. Photograph courtesy of Brooke Army Medical Center Medical Photography.Magnetic resonance imaging of the distal right arm. Coronal short T1 inversion recovery (STIR) image showing diffuse ulnar nerve enlargement (red arrow).Magnetic resonace imaging of the distal right arm. Coronal short T1 inversion recovery (STIR) imaging showing diffuse median nerve enlargement (red arrow).Thickening of the left greater auricular nerve. Photograph courtesy of Brooke Army Medical Center Medical Photography.Photomicrograph of punch biopsy specimen demonstrating superficial and deep dermal, non-caseating, epithelioid cell granulomas (black arrow), some forming preferentially around adnexal structures and nerves (hematoxylin and eosin stain, original magnification x 4).Photomicrograph of punch biopsy specimen demonstrating discrete, non-caseating, epithelioid cell granulomas around adnexal structures (black arrow, eccrine glands) and nerves (red arrow) within the dermis (hematoxylin and eosin stain, original magnification x 10).

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