Skip main navigation

Military Health System

Clear Your Browser Cache

This website has recently undergone changes. Users finding unexpected concerns may care to clear their browser's cache to ensure a seamless experience.

Corneal Collagen Cross Linking in the Military a Game Changer

Image of Corneal collagen cross-linking, known as CXL, the first and only treatment to date that is proven to stop Keratoconus, KCN, progression. Corneal collagen cross-linking, known as CXL, the first and only treatment to date that is proven to stop Keratoconus, KCN, progression.

For years, Keratoconus has been a disqualifying condition in the military, and a reason why refractive surgery is often denied to service members.

Keratoconus (pronounced Keh·ruh·tow·kow·nuhs), or KCN, is an eye condition where the front part of the eye (cornea) gradually thins out and bulges causing irregularity and blurred vision.

KCN may result from eye rubbing. It has also been linked to sleep apnea, asthma, allergy, eczema, vernal conjunctivitis, floppy eyelid syndrome, connective tissue disorders, or a family history of KCN. Historically, the primary treatment for KCN was contact lenses when eyeglasses were not sufficient to correct the irregular astigmatism. Severe cases were treated with corneal transplantation.

Navy Capt. (Dr.) John Cason, prior ophthalmology specialty leader and refractive surgery advisor, stated that, he reviewed about 2 to 5 sailor applicants per month for possible waiver for accession into the military due to KCN.

In 2016, the Food and Drug Administration approved corneal collagen cross-linking, known as CXL. This is the first and only treatment proven to stop KCN progression.

Air Force Col. (Dr.) Matthew Caldwell, ophthalmology consultant to the Air Force Surgeon General, called CXL a "readiness game changer." He noted that "KCN is of special interest to the military as the age range of impact nearly exactly overlaps years of active-duty service." The onset can happen before or after acceptance into the military when screening is too late.

"KCN impacts the ability to deploy and can degrade vision excluding careers in aviation, Special Forces, and in severe cases, even less visually intensive administrative work," added Caldwell.

Since the FDA approval, hundreds of service members have been treated with CXL. And a majority of these have been able to retain their military careers.

Air Force Col. (Dr.) Joseph Giovannini, cornea specialist at the David-Grant USAF Medical Center at Travis Air Force Base in California stated, "I have seen several military careers saved by the procedure."

Air Force Capt. Lowell DePalma, an aviator who had bilateral CXL, backed up Giovannini, "CXL has allowed me to keep my job and helped my future eye exams to be more predictable."

Currently, ophthalmology consultants are able to recommend acceptance waivers for military candidates with early KCN as long as they are able to show stability after CXL procedure.

"CXL has offered the possibility of military service for a group of candidates with mild symptoms from KCN," stated Cason. In the past, these volunteers didn't have the option of continued service due to restrictive guidelines that did not offer any flexibility with treatment. CXL has given these people the possibility of treatment, stability, and a future military service that were previously denied."

In the future, CXL may also significantly expand the options of vision-enhancing refractive surgery. In the past, service members with abnormal corneal scans were disqualified from refractive surgery. However, over the past decade, CXL plus refractive surgery outcomes have been favorable.

"The advent of CXL has helped tremendously to retain highly trained individuals and increase the applicant pool for the armed services," explained Air Force Lt. Col. (Dr.) James Townley, refractive surgery consultant to the Surgeon General of the Air Force.

As technology continues to advance, the use of CXL and refractive surgery will help more service members remain on active duty.

All authored materials constitute the personal statements of the names listed above and are not intended to constitute an endorsement by the Unites States Air Force or any other Federal Government entity

You also may be interested in...

Report
Jan 1, 2011

MSMR Vol. 18 No. 12 - December 2011

.PDF | 321.96 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Brief report: Births, active component, 2001-2010; Brief report: Numbers and characteristics of women in the active component, U.S. Armed Forces; Complications and care related to pregnancy, labor and delivery, ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 3 - March 2011

.PDF | 830.95 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Motorcycle and other motor vehicle accident-related deaths, U.S. Armed Forces, 1999-2010; Update: Heat injuries, active component, U.S. Armed Forces, 2010; Update: Exertional rhabdomyolysis, active component, U ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 2 - February 2011

.PDF | 818.25 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Causes of medical evacuations from Operations Iraqi Freedom (OIF), New Dawn (OND) and Enduring Freedom (OEF), active and reserve components, U.S. Armed Forces, October 2001-September 2010; Cruciate ligament ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 10 - October 2011

.PDF | 343.07 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Relationships between increasing outpatient encounters for neurological disorders and introductions of associated diagnostic codes, active duty military service members, 1998-2010; Alcohol-related diagnoses, ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 5 - May 2011

.PDF | 842.10 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Eye injuries, active component, U.S. Armed Forces, 2000-2010; Stress fractures, active component, U.S. Armed Forces, 2004-2010; Trends in emergency medical and urgent care visits, active component, U.S. Armed ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 9 - September 2011

.PDF | 306.33 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Associations between repeated deployments to Iraq (OIF/OND) and Afghanistan (OEF) and post-deployment illnesses and injuries, active component, U.S. Armed Forces, 2003-2010. Part II. Mental disorders, by gender ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 8 - August 2011

.PDF | 336.56 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Updates: Routine screening for antibodies to HIV-1, civilian applicants for U.S. military service and U.S. Armed Forces, active and reserve components; Surveillance Snapshot: Service members with hepatitis B, ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 6 - June 2011

.PDF | 843.84 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Duration of service after overweight-related diagnoses, active component, U.S. Armed Forces, 1998-2010; Noise-induced hearing injuries, active component, U.S. Armed Forces, 2007-2010; Acute gastroenteritis ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 4 - April 2011

.PDF | 1.01 MB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Absolute and relative morbidity burdens attributable to various illnesses and injuries, U.S. Armed Forces, 2010; Hospitalizations among members of the active component, U.S. Armed Forces, 2010; Ambulatory ...

Report
Jan 1, 2011

MSMR Vol. 18 No. 1 - January 2011

.PDF | 711.60 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Update: Malaria, U.S. Armed Forces, 2010; Diagnoses of overweight/obesity, active component, U.S. Armed Forces, 1998-2010; Multiple sclerosis, active component, U.S. Armed Forces, 2000-2009; Notices to Readers.

Report
Jan 1, 2011

MSMR Vol. 18 No. 11 - November 2011

.PDF | 393.78 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Norovirus outbreak associated with person-to-person transmission, U.S. Air Force Academy, July 2011; Notice to readers: Department of Defense laboratory capabilities for testing for norovirus infection; ...

Report
Jan 1, 2010

MSMR Vol. 17 No. 12 - December 2010

.PDF | 736.51 KB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: Numbers, proportions, and natures of conditions that are diagnosed for the first time within six months before retirement, active component, U.S. Armed Forces, 2003-2009; Osteoarthritis and spondylosis, active ...

Report
Jan 1, 2010

MSMR Vol.17 No. 4 - April 2010

.PDF | 1.21 MB

A monthly publication of the Armed Forces Health Surveillance Branch. This issue of the peer-reviewed journal contains the following articles: To readers of the Medical Surveillance Monthly Report (MSMR); Hospitalizations among members of the active component, U.S. Armed Forces, 2009; Ambulatory visits among members of the active component, U.S. ...

Skip subpage navigation
Refine your search
Last Updated: July 11, 2023
Follow us on Instagram Follow us on LinkedIn Follow us on Facebook Follow us on X Follow us on YouTube Sign up on GovDelivery